Preparation for air travel in a child with sickle-cell anaemia

Effect of Lisinopril on Microalbuminuria in Sickle Cell Anaemia Children: A Single-Blind Randomized Controlled Trial

Background Sickle cell nephropathy is a major cause of morbidity and mortality in sickle cell anaemia (SCA). Proteinuria contributes to progression of renal damage. Icroalbuminuria is an early feature of SCN and progression to advanced kidney damage is delayed if regression is achieved with angiotensin converting enzyme inhibitors. We aimed to ...

Sickle Cell Disease and Sickle Cell Anaemia

Sickle cell haemoglobin (HbS) results from an autosomal recessively inherited mutation in which the 17th nucleotide of the beta globin gene is changed from thymine to adenine and the amino acid glutamic acid is replaced by valine at position 6 in the beta globin chain. [1, 2]Sickle cells have a reduced deformability and are easily destroyed, causing occlusion of the microcirculation and a chron...

Anaesthesia in Patients with Sickle-cell Anaemia.

Sir,—We were very interested to read Dr. R. A. Browne's article on this subject (Brit. J. Anaesth. (1965), 37, 181) and feel that a case which we were requested to anaesthetize might be worthy of comment in this connection. The patient was a West Indian woman, age 27 years, gravida-4 with a long history of sickle-cell anaemia, for which she had received alkalis plus blood transfusions. She was ...

Sickle cell anaemia.

Sickle Cell Anaemia in a Changing World

Populations and their health are dynamic. Societal, environmental, and economic changes lead to changes in rates of birth, death, and disease, often described as transitions in mortality, demography, and epidemiology. The notion of epidemiologic transition provides an insight into the relationship between levels of overall mortality and the distribution of its causes [1–3], in which the greates...